TITLE: Canine pyometra: A model for the analysis of serum CXCL8 in inflammation
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Canine pyometra: a model for the analysis of serum CXCL8 in inflammation
Interleukin-8 (IL-8 or CXCL8) is a highly selective pro-inflammatory chemokine, that is elevated in sera of humans and animals with various inflammatory diseases. CXCL8 is possibly involved in uncontrolled inflammation and the development of a systemic inflammatory response syndrome (SIRS) and sepsis. Nevertheless, its behavior and precise properties in the course of inflammation are not fully ...
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Despite six decades of research, the pathogenesis of pyometra is still not completely understood. Recent investigations question whether the previous concept of considering cystic endometrial hyperplasia (CEH)–pyometra as a complex is correct. The pathogenesis of CEH appears to have a strong hormonal component, whereas the etiology of pyometra might be more influenced by the bacterial component...
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C-reactive protein (CRP) is a sensitive and specific marker of systemic inflammation in dogs, valuable for diagnosing and monitoring inflammatory diseases. The use of CRP in canine medicine has however been hampered by the lack of automated assays optimized for measuring CRP in this species. The need for improved CRP assays was the reason for initiating the current project, with the goal to gen...
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BACKGROUND Myocardial injury may contribute to unexpected deaths due to pyometra. To detect myocardial damage, measurement of cardiac troponin I (cTnI) is currently the most sensitive and specific method. The aims of the present study were to evaluate presence of myocardial damage in canine pyometra by analysis of cTnI, to explore whether myocardial injury was associated with systemic inflammat...
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تاریخ انتشار 2015